Combing the physical chemistry theories, artificial intelligence methods, and expertise in solid state chemistry, XtalPi empowers the pharmaceutical R&D process through the "experimental + computational" approach. By integrating modern laboratories and digital platforms, solid state R&D processes were efficiently promoted by the close interactions and fast iteration of experimental and computational progress.
- "Experimental + Computational" R&D Mode
XtalPi builds a platform integrating computational and experimental R&D capabilities, which takes full advantages of our data and service platform equipped with massive cloud computation resources. This mode can continuously optimize and iterate research and development results, accelerating the drug development process compared to traditional pharmaceutical solid-state research methods.
- Extensive Project Experience
XtalPi pharmaceutical solid form R&D team has extensive project experience, and has promoted a lot of small molecule pipelines to the IND (Investigational New Drug) application stage.
- Key Customers
Xtalpi provides pharmaceutical solid state R&D services to hundreds of customers around the world. Our key accounts cover 75% of the global TOP 20 pharmaceutical companies and major top pharmaceutical enterprises in China.
- Research Capability
XtalPi has been certified as a national high-tech enterprise in China. Our pharmaceutical solid state R&D team continues cutting-edge technological innovation. high-level academic papers in influential journals have been published and frequently cited.
Experimental solid-state formulation R&D
Polymorph/Salts/Cocrystal Screening and Evaluation
Crystallization Process Development
Solid Dispersion Formulation Development
Analytical Method Development
Solid-State Chemistry Computation Services
XtalCSPTM Crystal Structure Prediction
Virtual salt screening
Virtual cocrystal screening
Solvate propensity prediction
Solid dispersions propensity prediction
Crystal Structure Determination
Single crystal preparation and structure determination
MicroED crystal structure determination
Single crystal preparation
Cross validation between predicted forms and experimental forms to determine the energy ranking of experimentally obtained crystals
Risk assessment of form conversio
Recommendation of experimental conditions to prepare novel crystalline forms
Property predictions (solubility, morphology, mechanical properties, etc.) of crystalline forms in early-stage drug discovery
Single crystal preparation
X-ray powder diffraction（XRPD)
Solid State Analytical Laboratory
Solid State R&D Laboratory
Micro-electron diffraction （MicroED）